题目：Linking fluid shear stress with vascular oxidative stress
报告人：  Tzung K. Hsiai
Department of Biomedical Engineering and
Division of Cardiovascular Medicine
Viterbi School of Engineering and Keck School of Medicine
University of Southern California

主持人：熊春阳 副教授
时间：12月5日（周五）下午2:30
地点：2138cn太阳集团古天乐廖凯原楼2-102（会议室）

报告内容摘要：
Rupture of unstable plaque is a critical event in myocardial infarction and stroke. It has been suggested that plaque instability is caused by a dynamic imbalance in oxidative stress, inflammatory responses and proteolytic activities. Hemodynamics, specifically, fluid shear stress, on the plaque may lead to mechanical failure because the plaque is protruding into the lumen, focal and eccentric. In this context, the goal of this seminar is to gain insights into spatial and temporal variations in fluid shear stress and vascular oxidative stress. The development of micro electro mechanical systems (MEMS) sensors in our group have provided a means to undertake study of atherogenic hemodynamics (low shear stress and/or oscillatory shear stress) and vascular oxidative stress with a potential to localize early atherosclerosis.

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联系人：熊春阳，010- 62757940

Tzung K. Hsiai, M.D., Ph.D.
Mary G. and Robert G. Lane Early Career Chair Associate Professor of Biomedical Engineering and Cardiovascular Medicine
MEMS and nano sensors, reactive nitrogen species (RNS) and reactive oxygen species (ROS), vascular endothelial dynamics, and molecular imaging of atherosclerotic lesions.

Office: DRB 172
Phone: (213) 740-7236
Fax: (213) 740-0343
Email: hsiai@usc.edu

BACKGROUND
Dr. Hsiai received his undergraduate education from Columbia University, and MD from the University of Chicago. Dr. Hsiai completed his cardiology fellowship at UCLA School of Medicine, during which he also obtained a PhD in Biomedical Engineering in 2001. Dr. Hsiai is board certified by the American Board of Internal Medicine and Cardiovascular Disease. He holds a joint appointment with the School of Medicine as an attending physician at the Division of Cardiovascular Medicine. His research program is funded by the National Institutes of Health, American Heart Association, National Heart Foundation/American Health Assist Foundation. He is the Fellow of American College of Cardiology, recipient of NIH Physician Scientist Career Development Award, and American Heart Association John J. Simpson Outstanding Research Achievement Award.
RESEARCH
The central theme of Dr. Hsiai's research program is to embrace micro and nano systems to address fundamental cardiovascular questions. Using a micro-fluidic flow model, Dr. Hsiai's lab is investigating the mechanisms whereby hemodynamics regulates the development of coronary artery disease. His group is linking the effects of real-time shear stress on cardiac cell dynamics using Micro Electro Mechanical Systems (MEMS) sensors and molecular techniques. The current research objective is to study vascular inflammatory responses in the context of nitrogen oxide (NO) bioavailability using novel engineering methodology.

Dr. Hsiai's research interests include:
* MEMS and nano sensors
* Reactive nitrogen species (RNS) and reactive oxygen species (ROS)
* Vascular endothelial dynamics
* Molecular imaging of atherosclerotic lesions

His clinical interests are:
* Coronary artery disease
* Cardiac imaging
* Cardiac diagnostics