题目：Probing Functional Bio-Nano Interface
报告人：  Yaling Liu  博士
Department of Mechanical and Aerospace Engineering
University of Texas at Arlington

报告内容摘要：
Nanotechnology nowadays plays an increasingly important role in biomedical applications. Interfaces between nano- and bio- systems involve multiple physics such as solid mechanics, fluid mechanics, chemistry, and biology, across a wide range of length and time scales.  Biomolecules coated at material interfaces provide functional interfacial properties for various biomedical applications. We have developed novel immersed finite element and molecular dynamics based numerical methods for the simulation of bio-nano interfacial phenomena. At continuum level, we are studying blood-implants interaction, including artificial hearts, valves, bypass grafts, etc. At molecular level, we are using molecular dynamics and coarse-grained modeling to characterize the bio-nano interfaces. This talk will provide an overview of two types of bio-nano interfaces: DNA-nanopore interaction and nanoparticle targeted drug delivery. First, chemically functionalized nanopores have been used for DNA translocation and gene detection. We intend to probe the interaction and the translocation process of DNA through a model that links atomistic DNA-nanopore interaction to meso-scale particle dynamics. Critical interrelationships between physical properties of the nanopore, electric field strength, and translocation kinetics will be established, which not only advances the molecular-level understanding of the DNA-nanopore interface, but would also help design lab-on-chip devices for molecule based diagnosis.  Second, adhesion of nanoparticles onto cardiovascular walls plays a critical role in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. We intend to study the adhesion dynamics of nanoparticles with different shapes, bonding strengths, and physical configurations by coupling ligand-receptor binding dynamics with Immersed Finite Element Method. Non-spherical particle is found to contact and adhere to the wall much easier than spherical particle under the same configuration. This research work will result in fundamental and indepth knowledge on how shape affects the transport and targeting efficacy of nanomedicine carriers.

主持人：唐少强  教授
时间：12月19日（周五）下午2:00
地点：力学楼434会议室

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联系人：刘才山  62756177