讲座题目：报告一： Mesenchymal Stem Cell Collagen Microspheres for Cartilage Tissue Engineering
报告二：Effects of Collagen Matrix on Fates of Mouse Embryonic Stem Cells during Chondrogenic Differentiatio
报告人：Barbara P. Chan
时 间：9月7日（周二）下午1:30
地 点：廖凯原楼2-102会议室
主持人：葛子钢（特聘研究员）
报告内容摘要：
报告一内容摘要：Collagen microencapsulation is an emerging platform technology for tissue engineering. Many cells including mesenchymal stem cells (MSCs) can be entrapped in reconstituted collagen fibrous meshwork, resulting in formation of cell collagen microspheres. Applications of this technology in cartilage tissue engineering will be discussed. Specifically, bone marrow derived MSCs were microencapsulated in collagen microspheres and differentiated towards chondrogenic lineages. The differentiating MSCs remodeled the collagen microspheres into cartilage-like tissue micromasses. Finally, the efficacy of using these microspheres for cartilage repair in a rabbit model will also be discussed in this talk.
报告二内容摘要：Embryonic stem (ES) cells hold great potential in regenerative medicine although controlling their differentiation into homogeneous lineages is challenging. In this study, we aim to investigate the effects of reconstituted 3D collagen matrix on fates of mouse ES (mES) cells before and after induction for chondrogenic differentiation at different time points. Collagen microspheres provided a suitable microenvironment supporting mES cell growth and maintaining their undifferentiated status for certain period of time. At later time points, the proportion of undifferentiated mES cells gradually decreased, accompanied by increasing proportions of mesenchymal progenitor cells. This suggests the inductive role of collagen matrix in differentiating mES cells towards mesenchymal lineages. Moreover, both the initial collagen concentration and the time to induce differentiation significantly affected the fates of mES cells.
报告人简介：
Barbara P. Chan, 2009-Present, The University of Hong Kong, Associate Professor.
Barbara P. Chan.doc