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报告内容摘要：
Magnetic nanoparticles have long been an important class of biomaterials. Iron oxide nanoparticles, for instance, have been used in clinics as MR contrast probes, mostly for improving the visibility of lesions in reticuloendothelial system (RES) organs, such as liver and lymph nodes. Recently, a new set of chemistry has emerged, which allows one to prepare nanoparticles with fine control over a wide range of parameters, including size, shape, composition, magnetization, hydrodynamic size, surface coating and surface charge. Such a transition does not only affect the conventional applications of magnetic nanoparticles, but also opens many new avenues. The idea is to conceptualize a particle not only as a tiny magnetic crystal, but also as a platform of large surface-to-volume ratio. By harnessing the well developed surface chemistry, one can load a wide range of functionalities onto the particle surface. These include biovectors--such as peptides and antibodies--which are able to steer the migration of nanoparticles in a living subject and to accumulate them preferentially in areas of interests, such as in tumors. The nanoplatforms can be further loaded with imaging motifs or therapeutic agents, and as a consequence, to be upgraded as multifunctional nanogadgets of multimodal imaging capabilities or theranostic features. In this talk I will introduce some of the exciting projects on this topic I have been involved.

报告人简介：
Dr. Jin Xie received B.S. in chemistry in 2003 from Nanjing University, China. He came to the states in 2004 and obtained his Ph.D. in chemistry from Brown University in 2008 under the supervision of Dr. Shouheng Sun. His Ph.D. work focused on the synthesis and surface modification of magnetic nanoparticles. After graduation, he joined the Molecular Imaging Program at Stanford (MIPS), where he worked with Dr. Xiaoyuan Chen on developing inorganic-nanoparticle-based probes for multimodal imaging. In the summer of 2009, he joined the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) as a research fellow. He will be joining the Department of Chemistry, University of Georgia as an assistant professor this summer. His current research is focused on developing nanoparticle- or protein-based theranostic agents with combined imaging and therapeutic functions.