题目：Diamond-Enhanced Nanomedicine for Targeted Drug Delivery and Imaging

报告人：Dean Ho

时 间：5月13日（周一）下午4:00
地 点：校医院A-534会议室
主持人：席建忠

报告内容摘要：
    Nanodiamonds have emerged as promising candidates for drug delivery and imaging due to their unique surface properties. Nanodiamond-anthracycline compounds have mediated major improvements to drug delivery efficacy and safety. Most recently, NDX, a nanodiamond-doxorubicin agent, markedly enhanced the pre-clinical treatment efficacy of multiple drug-resistant tumors with no apparent myelosuppression, demonstrating potent drug binding and the absence of premature drug release [1]. Nanodiamonds bound to gadolinium have also resulted in contrast agents that are 12 times more efficient than clinical standards with among the highest ever reported per-gadolinium relaxivity values. This lecture will highlight recent advancements in the use if nanodiamond-anthracycline complexes towards the treatment of glioblastoma, a notoriously hard to treat form of brain cancer, as well as leukemia. In addition,diamond-based multimodal imaging/therapy approaches will be explored as potential clinically-relevant modalities [2]. The combination of these pre-clinical advancements in diamond-based nanomedicine and promising nanodiamond surface properties serves as a foundation for it's translational roadmap which will also be discussed [3].