题目：Co-registration of fluorescence diffuse optical tomography(fDOT) with Positron emission tomography (PET) and development of multi-angle fDOT”

报告人：Xiao Tong

时 间：5月20日（周一）下午3：00
地 点：校医院A-534会议室
主持人：任秋实

报告内容摘要：
    Introduction of the institution:The Institute of biomedical imaging (I?BM) of CEA (French Atomic Energy commission), centered its research program on biomedical imaging and aim at a better understanding of the brain functioning and the development of new therapeutics approaches of several diseases such as neurological disease and cancers. The department SHFJ (Frédéric Joliot Hospital Service) is one of the pioneering centers in Europe in the field of molecular imaging using the PET technique and one of few French centers disposing of an academic cyclotron and a radiochemistry unit. It proposes a multimodal approach of biomedical imaging in the fields of neurology, psychiatry, oncology and cardiovascular and metabolic disease. As a research unit the SHFJ is closely Close collaborations with major players in research from universities, INSERM, CNRS.
    The unit U1023 molecular imaging is a mixed INSERM-CEA research unit carries out research on the observation and analysis of the chemistry of life by non-invasive imaging methods?These imaging methods are: ?
    - Radioisotopic imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT).?
    - Optical imaging of fluorescence and luminescence chemistry?
    The applications concern principally the fields of oncology, neurology and of metabolic and inflammatory disease.
    Co-registration of fluorescence diffuse optical tomography (fDOT) with Positron emission tomography (PET)
    The present study concerns the image processing of fluorescence diffuse optical tomography (fDOT). In oncologic imaging, there is a clear trend towards multimodal imaging of tumor as the best way to provide relevant information on a significant number of various cancer hallmarks. The complexity of tumors interactions with their environment calls for imaging methods capable of detecting a diversity of tumor hallmarks. Different studies have demonstrated the potential interest of combining optical imaging with other modalities. The most common approach is the combination with CT images. Recent studies have demonstrated the potential interest of combining fDOT with PET. This combination serves to enhance the molecular information originating from a single subject at a given time point. Given the resolution of small-animal PET and fDOT scanners (1–2 mm), accurate and reliable co-registration between both modalities is essential.
    An automatic method to co-register the fDOT images with PET images has been developed to correlate all the information from each modality. This co-registration method is based on automatic detection of fiducial markers (FM) present in both modalities. The particularity of this method is the use of optical surface image obtained in fDOT imaging system, which serves to identify the Z position of FM in optical images. We tested this method on a model of mice bearing tumor xenografts of MEN2A cancer cells that mimic a human medullary thyroid carcinoma, after a double injection of radiotracer [18F] 2-fluoro-2-Deoxy-D-glucose (FDG) for PET imaging and optical fluorescent infrared tracer Sentidye. With the accuracy of our method, we demonstrated that the signal of Sentidye is present both in the tumor and surrounding vessels.