报告内容摘要：
    Tissue engineering has been rapidly developed in recent years as a promising approach in treating diseases and injuries by combining cells, biomaterial scaffolds, and biologically active molecules. Many engineered tissues and organs such as skin and cartilage have already been used for clinical applications. Three-dimensional biomaterials and scaffolds play an important role in tissue engineering by providing necessary interim support for cell adhesion, proliferation, and phenotypic differentiation; offering biochemical and biophysical cues to modulate the new tissue formation. A number of porous scaffolds and biomimetic biomaterials have been prepared from biodegradable polymers and extracellular matrices to mimic the in vivo nano- and micro-environments surrounding cells. This lecture will highlight the latest progress, future trends and challenges of porous scaffolds and biomimetic biomaterials, and introduce a few typical scaffolds such as funnel-like porous scaffolds, hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers, and autologous scaffolds. The funnel-like porous scaffolds can be prepared by using ice particulates as a template and have a unique pore structure with large open pores on the top surface that communicated with interconnected inner bulk small pores within the matrix. The hybrid scaffolds can be prepared by forming collagen sponge or microsponge in the openings of porous skeletons of mechanically strong synthetic polymers. The hybrid scaffolds have the advantages of both types of polymers. Autologous scaffolds can be prepared by 3D culture of cells in a template that can be selectively removed after cell culture. The autologous scaffolds have excellent biocompatibility and minimize host response for implantation.

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