报告内容摘要

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Traditional characterization methods to evaluate the performance of orthopedic biomaterial in repairing bone defect mainly focus on mechanical behavior, degradation properties, surface chemistry and so on. However, though researchers have realized that the degradation products of implants should be non-toxic, the changes and influence of in vivo microenvironment pH (Micro-pH) brought by their degradation has often been neglected. The aim of this study is to monitor the relationship between the repairing performance of implants and its Micro-pH, and propose the new idea to take Micro-pH as a new evaluation index.  Different biomaterials powders are filled into rat models of osteoporotic bone defect. The Micro-pH surrounding biomaterials-biology interface was monitored with needle combination pH microelectrodes, at different phases of healing. Micro-CT scanning, goldner’s trichrome and TRAP staining were employed to detect the performance of specific implants. However, besides Micro-pH, other parameters, such as beneficial element, would influence in vivo performance of implants. So, the in in vitro experiments with strickly controlled variables were performed to examine the effect of pH on oBMSCs and RAW 264.7 cells. Our results indicate that, though other parameters would influence the performance of orthopedic implants, weak microenvironment pH is also an indispensible factor, which is vital to ameliorate the imbalance between bone formation and absorption under osteoporotic bone remodeling microenvironment. Besides, needle combination pH microelectrode can be employed to detect biomaterials in vivo Micro-pH, and could help to find specific suitable Micro-pH condition for specific biomaterials.

报告人简介

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潘浩波，研究员，博士生导师，中国医促会骨科疾病防治专业委员会常务委员，骨科生物材料学组副主任委员，中国科学院深圳先进技术研究院生物医药与技术研究所副所长，人体组织与器官退行性研究中心主任，深圳市海洋生物医用材料重点实验室主任，深圳市引进海外高层次孔雀人才B类计划，深圳市“骨与关节退行性疾病防治新技术团队”孔雀团队核心负责人。

教育背景

·         2007年获香港大学博士学位

主要工作经历

·         2010-2012: 香港大学研究助理教授

·         2007-2010: 香港大学博士后

研究兴趣

骨科植入生物活性材料研发；海洋医用材料研发等

代表论文

1       Yuhui Shen, Waiching Liu, Chunyi Wen, *Haobo Pan, Ting Wang, Brian W Darvell, William W Lu and Wenhai Huang, Bone regeneration: importance of local pH –strontium-doped borosilicate scaffold. Journal of Materials Chemistry 2012; 22: 8662-8670 (IF=6.626)

2.       Yuhui Shen, Waiching Liu, Kaili Lin, *Haobo Pan, Songlin Peng, Paul Wen, Lianfu Deng, Xiaoguo Liu, William W. Lu, Jiang Chang, pH effects on solid/liquid interface PH：A critical factor for osteoporotic bone regeneration .Langmuir 2011; 27: 2701-2708 (IF =4.384)

 

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