报告内容摘要

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Titanium and its alloys are extensively used for clinical implants, because of their excellent mechanical properties, and good biocompatibility. The long-term clinical researches show that titanium implant is confronted with the following problems: poor bone regeneration or slow regeneration, poor integration with surrounding bone tissues, and limited service life. The events after implantation include interactions between tissues and implant surfaces. Therefore, it is extremely important to achieve the implant with good comprehensive performance through surface modification. In recent years, further immobilizing the bioactive molecules, such as therapeutic agents or growth factors, with bone-like mineral layer on titanium implants is becoming the research focus in the biomaterials fields. Such surface modification technology could incorporate osteoinductivity and osteoconductivity into the design of the supporting biomaterial, thus improving the osseointegration and extending the service life.

报告人简介

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教育背景

·         2007.09-2013.03   华中科技大学              生物医学工程              工学博士

·         2008.03-2009.03   Yonsei Univ.  Atomic-Scale Surface Science Research Center    Exchange Student

·         2003.09-2007.06   华中科技大学              生物医学工程              工学学士

主要工作经历

·         2013.11-至今: 浙江理工大学            生命科学学院              讲师

代表论文

1.       Cen Chen, In-Seop Lee*, Sheng-Min Zhang, Hyeong Cheol Yang. Biomimetic apatite formation on calcium phosphate-coated titanium in Dulbecco’s phosphate-buffered saline solution containing CaCl2 with and without fibronectin. Acta Biomaterialia 2010;6:2274-2281.

2.   Cen Chen, Zhiye Qiu, Sheng-Min Zhang, In-Seop Lee*. Biomimetic fibronectin/mineral and osteogenic growth peptide/mineral composites synthesized on calcium phosphate thin films. Chemical Communications 2011;47:11056-11058.

3.   Cen Chen, Han Li, Xiangdong Kong, Sheng-Min Zhang, In-Seop Lee*. Immobilizing osteogenic growth peptide with and without fibronectin on a titanium surface: effects of loading methods on mesenchymal stem cell differentiation. International Journal of Nanomedicine 2015;10:1–13.

 

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