Abstract

Important features make nanoparticles and microspheres interesting for in vitro and in vivo applications: biocompatibility, biodegradability, transport capacity, surface functionalization with biological active molecules, binding of fluorescent (Quantum Dots) or radioactive markers, increasing surface area with decreasing size, organ-specific targeting. The development of magnetic responsive microspheres has brought an additional driving force into play. These magnetic forces can be used for the separation and cleaning of bone marrow cells and many other cell sub-types with immunomagnetic beads for clinical transplantation and for further clinical studies.

The possibility to target and hold magnetic particles at pre-selected anatomical sites makes them very efficient and also highly specific for various clinical applications. Apart from solving the magnetic targeting problems (the limited distance of retention capacity), intensive efforts are ongoing in the development of biocompatible magnetic carriers (e.g., magneto-liposomes). They can be used as sources to increase local temperature (hyperthermia), for local contrast enhancement in MR imaging, for local drug treatment and for genetic therapy. The release of drugs, nuclides or genetic vectors can be stimulated by the defined non-lethal temperature enhancement induced by a defined external electromagnetic field with specific frequency. The improvement of biocompatibility and enhancement of circulation time of carriers is in permanent discussion in order to reach a breakthrough in use of in vivo application.

At the moment, the accepted clinical applications are the in vitro separation of stem cells for transplantation, the use of modified nanoparticles for the contrast enhancement in magnet resonance imaging and local hyperthermia treatment of cancer. The development and application of drug-carrier systems for magnetic guidance and controlled delivery of drugs, genetic material, and stem cells to the target are the most exciting topics of magnetic carrier discussions. The possibilities and limitation of clinical application will be discussed.

报告人简介

Wolfgang Schütt is Professor Emeritus and Lecturer, Department of Biotechnology, University of Applied Sciences, Austria. He received his Ph.D. degree “rerum naturalium” with “summa cum Laude” in Experimental Physics in 1973, and  then received National Award for Science and Techniques (1. Klasse) of GDR and University Award for Research of University Rostock. In 2012, he was a Head of International Scientific Advisory Board. His research is in the field of  biomembrane physics and biophysical single cell characterization in biomedicine, and he has published books and papers more than 110 and given over 80 invited talks in Europe, Northern America and Asia. He also organized 15 international conferences.

联系人：冯翠云 62756702