报告内容摘要

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Design of bioactive materials that deliver precise regulatory signals to control stem cell fate for regenerative medicine has been a crucial issue currently in the field of biomaterials. Biomaterials serve as not only scaffolds and delivering vehicles, but also powerful artificial cell niche that direct specific cellular responses and tissue regeneration at the molecular level by adjusting the biophysical and biochemical properties of biomaterials, such as chemical functionalities, topography, mechanical properties, bioactive ligands, and their spatial and temporal presentations. Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted. In recent years, stem cell- and biomaterial-based strategies for nerve regeneration have attracted extensive attentions. In our group, we focus on the regulation of several types of stem cells, including neural stem cells, adipose stem cells, and umbilical mesenchymal stem cells by designing novel biomaterials for central nervous system regeneration. We have found that the surface chemistries of biomaterials could direct stem cell adhesion, proliferation, and differentiation. And the stem cells cultured on the materials with hierarchical alignment and soft mechanical properties will favor neurogenic lineage. Furthermore, we developed several bioactive hydrogels base on hyaluronic acid, self-assembling peptide, and fibrin, respectively for CNS regeneration.

报告人简介

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王秀梅，教授，博士生导师，清华大学材料学院再生医学与仿生材料研究所副所长。发表生物材料相关SCI论文60余篇。曾荣获2011年度国家自然科学二等奖；2010-2011年度中华医学科技奖三等奖；2014年度山东省科技进步一等奖；2012年度清华大学“学术新人奖”；入选教育部2013年度“新世纪优秀人才支持计划”和第12届霍英东教育基金会青年教师基金。担任中国生物材料学会青年委员会委员；科普工作委员会委员；中国机械工程学会表面工程分会生物材料表面工程专委会委员；以及中国硅酸盐学会特种陶瓷分会理事。

教育背景

   09/2000-01/2005: 工学博士，清华大学，材料物理与化学专业

   09/1996-07/2000: 工学学士，清华大学，材料科学与工程专业

工作经历

   2008-至今：清华大学材料学院

   2006-2008：美国麻省理澳门太阳娱乐网站官网生物医学工程中心，博士后

   2005-2006：美国罗切斯特大学医学院骨科研究中心，博士后

研究兴趣

神经组织再生修复；生物矿化机理研究及骨牙硬组织再生修复等

 

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