报告内容摘要：

It has been reported that the presence of magnesium in the bone system is beneficial to bone growth and play a key role in bone remodeling and skeletal development. Thus, we have specifically designed new bone substitutes containing surface treated magnesium micro-particles to deliver proper amount of magnesium ions for simulating in vivo formation. The results of in vitro experiments demonstrated that the release of magnesium ions at 50-100 ppm/day could enhance the expression of early bone markers and also the late bone marker as compared to the control, which suggested the specific amount of magnesium ions is participating in the bone formation process. The effect of magnesium ions to osteoclastogenesis also indicated that the released magnesium ions was able to suppress osteoclasts differentiation. The volume of newly formed bone in the Mg-contained sample was found to be 80% higher than the control in the rat animal model but bone resorption was found in the sample with higher concentration of magnesium ions. Hopefully, hydrogen gas accumulation was not found in both treated and untreated samples. The compressive modulus of new bone substitutes generally maintained during the test. In conclusion, the present results demonstrate that the concept of the use of magnesium ions to stimulate bone formation in vivo is promising

报告人简介：

杨伟国博士为现任香港大学医学院矫形及创伤外科学系Tenure副教授。在本科学习期间, 主修材料科学，其后在香港大学医学院修读硕士和博士研究生课程, 主攻有关矫正脊柱畸形病症的研究工作。研究范围涵盖了脊柱畸形外科矫正、植入性骨科矫形器械设计和发展、组织工程学、生物医学材料发展、生物医学材料对细胞及活体的反应等等。他先后在有关骨科医学、医学材料及材料科学的国际性期刊发表了超过130篇SCI论文。此外, 在他团队的研究成果中, 共获取三十多个由美国专利发明局或其他国家颁发的发明专利。另外，他联同刘耀南教授和张文智教授创立了OrthoSmart Limit?d，兼任公司行政总裁，旨在把他们研发的成果转化为产品，让骨科病人能够得到最佳的治疗。

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