报告一：Bone Regeneration: from intramembranous to endochondral pathway
 
报告人 Fang Yang (阳芳)
Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands
 
主持人：熊春阳 教授
时间：10月23日（周五）下午1:30
地点：廖凯原楼2-401
 
报告内容摘要：

With the potential to overcome the drawbacks of the current autografts and allografts, bone tissue engineering undoubtedly has been suggested as a promising technique for reconstructing bone defects. However, until recently, the clinical translation of this strategy is still unsatisfactory. Lack of timely and sufficient vascular supply, resulting in immediate cell death after implantation, is generally thought to be the cause of failure of the cell-scaffold constructs in patients. To overcome this issue, a potential strategy is to differentiate cells in a metabolically less-demanding and angiogenic pathway, i.e. along the endochondral ossification pathway, as this seems to hold promise for achieving better cell survival and vascularization of the implanted constructs in vivo. Nevertheless, compared to the available knowledge on bone regeneration via the intramembranous pathway, such an endochondral approach is still in its infancy. In this presentation, I will talk about our latest research work on endochondral bone tissue engineering, focusing particularly on 1) exploiting new porous scaffolds for bone regeneration applications, 2) establishing a cell-scaffold model for studying endochondral bone formation, 3) testing the applicability of endochondral approach with different scaffold materials, and 4) investigating the optimal in vitro priming time for the creation of cartilage templates.
 
报告人简介

Dr. Fang Yang is a biomaterial scientist and interested in the development and evaluation of novel biomaterials-based approaches for tissue regeneration and the controlled delivery of drugs or growth factors. She obtained her PhD degree from National University of Singapore in 2005 under supervision of Prof. Seeram Ramakrishna. After that she joined Prof. John Jansen’s group at Department of Biomaterials in Radboud University Medical Centre in the Netherlands until now.
Her current research focuses on the development of nanofibrous matrix as extracellular matrix with incorporation of therapeutic agents for bone and periodontal tissue regeneration. She is also interested in local drug delivery to prevent implant associated infections. Her expertise lies in biopolymers and biocomposites, electrospinning technique and biomaterials characterization (both physico-chemical and biological evaluation). She has published more than 40 journal articles and served as a peer reviewer for about 10 journals in the related field.
 
 

 
报告二：Functional Ligament Tissue Engineering with Electrospun Microcrimped Fibers
 
报告人  趙本秀 副教授
國立台灣大學醫學工程研究所
 
主持人：葛子钢 研究员
时间：10月23日（周五）下午2:30
地点：廖凯原楼2-401

报告内容摘要：

Fiber structure and order greatly impact the mechanical behavior of fibrous materials. In biological tissues, the nonlinear mechanics of fibrous scaffolds contribute to the functionality of the material. The nonlinear mechanical properties of the wavy structure (crimp) in collagen allow tissue flexibility while preventing over-extension. A number of approaches have tried to recreate this complex mechanical functionality. We generate microcrimped fibers by briefly heating electrospun parallel fibers over the glass transition temperature or by ethanol treatment. Degree of crimpness can be further modulated by incorporating a sacrificial component to modulate material porosity. The crimp structure is similar to those of collagen fibers found in native aorta, intestine, or ligament. Using poly-L-lactic acid (PLLA) fibers, we demonstrated that the bulk material exhibit changed stress-strain behaviors in correlation to the degree of crimp, similar to those observed in collagenous tissues. In addition to mimicking the stress-strain behavior of biological tissues, the microcrimped fibers are instructive in cell morphology and promote ligament phenotypic gene expression. This effect can be further enhanced by dynamic tensile loading, a physiological perturbation in vivo. This rapid and economical approach for microcrimped fiber production provides an accessible platform to study structure-function relationships and a novel functional scaffold for tissue engineering and cell mechanobiology studies.

报告人简介：

Dr. Pen-hsiu Grace Chao is the Associate Professor of Biomedical Engineering at National Taiwan University, in Taipei, Taiwan.  She is the director of the Cellular and Tissue Engineering Laboratory there since 2008.  Before joining NTU, she conducted postdoctoral research in cartilage tissue engineering with Dr. Gordana Vunjak-Novakovic at Columbia University.  Also trained in Columbia, Dr. Chao worked with Dr. Clark Hung to study mechanobiology of chondrocytes.  Currently Dr. Chao’s research interests are focused on building biomaterial platforms to study the interactive relationships between the physical microenvironment and mechanosensing.  Dr. Chao was awarded fellowship from the Arthritis Foundation and elected a Rising Star at the BMES Cellular and Molecular Bioengineering meeting.
 
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