报告摘要：

I will describe the invention and development of new applications in assembly, biodiagnostics, bio-imaging and anticancer drug delivery based upon novel nanoparticle constructs. In the first section of my talk, I will introduce a new method for asymmetrically functionalizing gold nanoparticles (AuNPs) with oligonucleotides and programming their assembly into complex higher order architectures. Then, I will talk about biodiagnostic applications of DNA-AuNPs for the detection of enzyme inhibitors, cancer biomarkers and metal ions based upon the distant-dependent optical and cooperative melting properties of the DNA-AuNPs, followed by exploring how DNA-AuNPs can be used as efficient vehicles to conjugate and deliver Gd-based MRI contrast agents and anticancer drug into cells, respectively. In the second section of my talk, I will talk about PLGA-PEG based polymeric nanoparticles as drug delivery carriers for the treatment of cancer, cardiovascular disease and obesity. In particular, a siRNA and anticancer drug co-delivery approach has been developed for the treatment of multiple drug resistance (MDR) tumor. The combination of chemotherapy with RNAi approaches to suppress the expression of proteins involved in the emergence of drug-resistance represents a promising synergistic strategy to circumvent or reverse acquired chemoresistance. This combination therapeutic approach can sensitize cancer cell to chemotherapeutics and shows superior tumor inhibition compared to the chemotherapeutics administered as a monotherapy.
 
报告人简介：

Dr. Xiaoyang Xu is an assistant professor in the Department of Chemical, Biological and Pharmaceutical Engineering at New Jersey Institute of Technology. Before that, he was a joint NIH postdoctoral fellow in the laboratories of Professors Robert Langer at MIT and Omid Farokhzad at Harvard Medical School. His research mainly focuses on the development of novel biomaterials and nanomedicine approaches for a broad range of biomedical applications including diagnostics, imaging and therapy. He completed his Ph.D. in Material Chemistry at Northwestern University under the supervision of Prof. Chad Mirkin. He received his B.E. in Chemical Engineering from East China University of Science and Technology in China. Dr. Xu has received multiple awards including Ruth L. Kirschstein National Research Service Award, AACR Scholar-in-Training Award, Chinese Government Award for Outstanding Chinese Students Study Abroad, and 1000 Plan Professorship for Young Talent.