报告内容摘要：

The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of inflammation and autoimmune disorders. Interestingly, the gene encoding the master transcription regulator of the Notch pathway, Rbpj, is among the recently identified new rheumatoid arthritis risk loci yet the functional significance of Notch-RBP-J signaling in pathogenesis of rheumatoid arthritis is unclear. During the past several years, we and others have described a key regulatory role of the Notch pathway in innate immune and inflammatory responses. Notch1-RBP-J axis promotes inflammatory macrophage polarization while a Notch target gene Hes1 dampens inflammation by attenuating macrophage chemokine production. Such regulatory patterns impose positive and negative checkpoints on inflammatory responses and may have potential implications for pathogenesis and therapy of autoimmune and inflammatory disorders such as rheumatoid arthritis.
 
报告人简介：

Xiaoyu Hu received her Bachelor of Medicine degree from Beijing Medical University and obtained her Ph.D. degree in immunology from Cornell University. After a brief postdoctoral training, she was promoted to Instructor and then Assistant Scientist at the Research Division of the Hospital for Special Surgery located in the New York City. She established her independent research laboratory in 2009 and in the next year joined the faculty of Weill Cornell Medical College as a tenure track Assistant Professor. In 2014, she joined Tsinghua University School of Medicine and led the Laboratory of Immune and Inflammatory Signaling. Currently she is a Principal Investigator at Institute for Immunology, Tsinghua University and Associate Director, Department of Basic Medical Sciences at Tsinghua University School of Medicine.   
Dr. Hu’s research aims to better understand the signal transduction networks that control macrophage activation and to identify new therapeutic targets that modulate macrophage functions in autoimmune and inflammatory conditions. One focus of Dr. Hu’s laboratory is to uncover signaling pathways as well as transcriptional and translational mechanisms that regulate macrophage responses to innate immune stimuli. Dr. Hu’s work has been funded by agencies including U.S. National Institutes of Health (R01), American College of Rheumatology, Lupus Research Institute, the National Natural Science Foundation of China, and Minister of Science and Technology of China and has been reported by news media such as Time Online.  
Dr. Hu has published over 30 articles in journals including Nature Immunology and Immunity (H index 25). She is the recipient of multiple awards including Young Women Investigator Award from International Cytokine Society, U.K. Royal Society Newton Advanced Fellowship, Young Scholar Award from U.S. Arthritis Foundation, China 1000 Young Talent Program Award, and China NSFC Young Investigator Award. Dr. Hu also served as ad hoc reviewer for a number of scientific journals and grant reviewer for major funding agencies including U.S. National Institutes of Health, U.S. Department of Defense, American College of Rheumatology, National Natural Science Foundation of China, and Ministry of Education of China.
 
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