报告内容摘要：

Responsive systems have recently gained enormous attention in the areas of bioimaging and drug delivery on account of their ability to release biologically active molecules with spatial and temporal control through the means of regulated light stimuli. We have developed several responsive multifunctional nanoparticles for targeted bioimaging and controlled drug delivery in disease therapy.1-12 To overcome the issues of photon scattering and low optical response in biological tissues, we have fabricated integrated nanoparticles as exogenous contrast agents for enhancing the capability of bioimaging modalities, discovered a strategy of using porous nanoparticles to prevent undesired aggregation of biological dyes for enhanced bioimaging, and developed self-assembled nanoparticles for photo-tunable bioimaging in order to visualize different stages of cell evolvement. In the follow-up research, we have synthesized several types of responsive nanoparticles for fluorescent, two-photon, three-photon, and photoacoustic bioimaging as well as bimodal bioimaging in vitro and in vivo. These responsive therapeutic nanoparticles can simultaneously target diseased cells, enable the location to be imaged by optical methods, and release therapeutic drugs to the diseased cells by commands. Thus, the responsive nanoparticle-based systems could perform four important roles: (1) nanocarriers for drug delivery, (2) phototriggers for drug release, (3) fluorescent chromophores for cell imaging, and (4) photo-switchable fluorophores for real-time monitoring of drug release. The responsive bioimaging and drug delivery strategy developed by us could be applied to existing drugs or experimental compounds that would benefit from longer circulation time or better targeting, which paves the way for developing next generation of therapeutics.
 
报告人简介：

Yanli Zhao，Associate Professor
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences,
Nanyang Technological University, 21 Nanyang Link, Singapore, 637371

Yanli Zhao is currently a Tenured Associate Professor at School of Physical and Mathematical Sciences as well as School of Materials Science and Engineering in Nanyang Technological University, Singapore. He received his B.Sc. degree in Chemistry from Nankai University in 2000 and his Ph.D. degree in Physical Chemistry there under the supervision of Professor Yu Liu in 2005. He was a postdoctoral scholar with Professor Sir Fraser Stoddart at University of California Los Angeles (October 2005 to December 2009) and subsequently at Northwestern University (January 2010 to August 2010). He has published over 290 scientific papers with an H-index of 55, and received several international awards including the ACS Applied Materials & Interfaces Young Investigator Award in 2017, the Singapore National Research Foundation Investigatorship in 2017, the Asian and Oceanian Photochemistry Association (APA) Prize for Young Scientist in 2016, the TR35@Singapore Award in 2012, the Singapore National Research Foundation Fellowship in 2010, and UCLA Chancellor’s Award for Postdoctoral Research in 2010. His current research focuses on the development of integrated systems for diagnostics and therapeutics, as well as porous materials for energy storage and catalysis.
 
 
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